Breast-clapping dance is one of the most representative intangible cultural heritage dances in the Minnan region. The work aims to excavate the cultural genes contained in the breast-clapping dance and realize their application in modern design. The genetic pedigree map was used in this research to study the breast-clapping dance culture. Through the analysis on the cultural origins and artistic characteristics of the breast-clapping dance, the dominant cultural genes and recessive cultural genes contained in the breast-clapping dance culture were systematically explored and summarized, and then a genetic pedigree map of the breast-clapping dance culture was formed. Based on the genetic pedigree map, the design application model based on the cultural genetic pedigree of the breast-clapping dance was constructed by integrating modern design methods, user needs and other factors, so it could be used to guide product design practice. With the seasoning bottle as the design object, by referring to the pedigree map and the design application model, the corresponding combination of breast-clapping dance culture genes were extracted, and these genes were applied to design of seasoning bottles after design translation, so as to realize the design transformation and application of the breast-clapping dance culture gene. The cultural genetic pedigree map can clearly and intuitively present the information of various dominant and recessive cultural genes contained in the breast-clapping dance culture, and it can make the dominant and recessive cultural genes to be expressed in an orderly and logical way. According to the cultural genetic pedigree map, a transformation model of cultural gene design can be constructed to realize the design and application of breast-clapping dance culture resources. The research ideas and methods can provide reference for the innovation and regeneration design of various intangible cultural heritage.