The work aims to promote innovative design research of traditional patterns, with bead patterns as the object and cultural and creative products as the carrier through cross domain combination of semiotics theory and shape grammar, to achieve innovative design transformation of traditional elements and enhance the cross domain design practice and theoretical research of semiotics. The historical literature of traditional elements such as bead patterns were analyzed and elaborated from four dimensions of design semiotics:context, language structure, semantics, and pragmatics. Then, using shape grammar, typical pattern symbols were evolved and re-designed, achieving innovative development in the application of bead patterns in cultural and creative products. Visual symbols with strong suitability and applicability were analyzed and elaborated, and innovative design applications were carried out according to the logical expression of their internal structure, achieving innovative design applications of traditional patterns and interdisciplinary research in semiotics. In conclusion, the innovative design of bead patterns in cultural and creative products not only enriches the added value of traditional patterns, promotes their innovative development and translation, but also constructs a comprehensive and systematic visual symbol of bead patterns based on the cross disciplinary foundation of semiotics and shape grammar, providing a rich theoretical and practical basis for the innovative design research of traditional patterns and the cross disciplinary development of semiotics.